Monday, November 30, 2009

Plastics Chemical Phthalate May Lead to Preterm Birth

Pregnant women who are exposed to higher levels of an increasingly controversial chemical in certain plastics may deliver their babies slightly earlier than women with less exposure, results of a study suggest.

The chemical, DEHP - short for di(2-ethylhexyl)phthalate - is a "plasticizer" used widely in consumer products to help make vinyl plastic soft and flexible.

"Exposures (to DEHP) are ubiquitous," Dr. Robin M. Whyatt from Columbia Center for Children's Environmental Health in New York City told Reuters Health. DEHP breakdown products "have been detected in 95% of the general U.S. population."

In recent preliminary studies, DEHP exposure has been linked to some health risks. In animal studies, for example, exposure to this and other so-called phthalates has been linked to lower-weight babies and shorter pregnancies.

In preliminary human studies, prenatal DEHP exposure has been shown to affect the timing of labor; however, the findings have been mixed.

They gauged DEHP exposure by measuring four DEHP breakdown products in urine samples collected from the 311 African American or Dominican women aged 18 to 35. All of the women were living in New York City and were in their third trimesters.

The team found that the higher the level of DEHP breakdown products in the mothers' urine during pregnancy, the earlier the infant was born, Whyatt told Reuters Health. Babies with the highest level of exposure were born about five days earlier than those exposed to the lowest levels.

It's important to note, the researchers say, that the women in the study delivered their babies at or near term. However, if prenatal DEHP exposure were to lead to more infants being delivered prematurely, on average, this could be cause for concern.

Steve Risotto, Senior Director, Phthalate Esters, at the American Chemistry Council industry group, noted that two earlier studies contradicted the current one, showing opposite effects. "There was also no association found between phthalate exposure and prematurity, as all of the births were full term," he told Reuters Health.

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